一、团队简介

感染与修复药理研究室紧紧围绕国家急需解决的困扰广大人民健康的疾病包括代谢性和炎性疾病靶器官感染免疫损伤等进行基础和临床转化研究，团队结合临床样本利用代谢组学、蛋白组学、糖生物学、糖芯片技术等先进研究手段和方法筛选新的疾病靶点，并在临床、动物和细胞水平进行验证和分子机制研究。以靶标及发病机制的核心环节为出发点，筛选天然产物有效成分或FDA批准药物，并对药物进行体外修饰和高分子材料包裹，提高药物生物利用度和病灶靶向性，为开发天然产物新用途及老药新用提供实验依据。团队共有成员7人，其中正高职2人，副高职3人，实验员1人，硕士生导师5人，太阳集团www0638至善教学名师1人，双创博士2人，海外研究经历者4人。团队近年来主持国家自然科学基金、江苏省自然科学基金、无锡市自然科学基金、教育部重点实验室专项等十余项等，担任省级学会理事、青年委员等，承担省市级和校级教学课题多项，获得省市级和校级教学成果奖多项，发表高质量SCI论文近百篇，申请或授权国际和国内专利数十项。欢迎各位同学加入感染与修复药理研究室。

二、团队负责人简介

邱丽颖，女，教授，内科学博士，毕业于福建医科大学。现任江苏省高等学校医药教育研究会副理事长、江苏省药理学会常务理事、江苏省生理学会理事。主要从事与慢性病相关的血管机制与中药药理学研究。主要参与科技部重大新药创制、国家自然科学基金、教育部重点实验室专项等5项，主持省、市级科研项目4项，医院和企业委托项目10项。在Neural Regen Res, Acta Pharma Sinica，Physiology sinica, European Review for Medical and Pharmacological Sciences，medicine hypotheses，Molecular Medicine Reports，International Journal of Molecular Medicine，药学学报、中国药理学通报、中国药学杂志、中成药等国内外期刊发表科研论文140余篇。授权专利3项，公开6项，获市及行业联合会等科技进步奖7项，参编专著2部。主持与主要参与科技部重大新药创制、国家自然科学基金等省级及以上科研项目10余项；以第一发明人已授权专利13项；近五年在国内外期刊发表科研论文15篇。曾主要负责教育部特色专业建设、省重中之重教改课题、省级精品课程建设等质量工程；主编国家规划教材3部；获得省、市级优秀教学成果奖9项。主讲课程获批江苏省首批线上一流课程。

三、团队成员简介

孙海建，男，病理生理学博士，校聘教授。南京医科大学病理学与病理生理学博士，新加坡国立大学博士后，主要从事代谢性和炎性疾病靶器官损伤和药物干预研究。近年来以第一作者和通讯作者在Gut、JAR、Redox Biology等发表SCI论文40余篇，中科院SCI期刊分区1区10篇，10分以上论文9篇。Google Scholar引用超2800次，H指数29。主持或完成国家自然基金面上项目、江苏省科协青年托举工程等项目。担任Burns & Trauma，Traditional Chinese Medicine等杂志青年编委，Front Pharmacol和Life杂志特邀编辑，担任Medicinal Research Reviews、Diabetes等期刊审稿人。

胡静，女，生物学博士，副教授，1979年生。博士毕业于德国柏林自由大学。主要从事糖化学生物学专业：一、天然糖类片段的免疫活性研究和挖掘；二、肿瘤精准诊疗和干细胞培养多功能糖基生物材料的研究开发。研究成果发表于Angew. Chem. Int. Edit.、Chemical Engineering Journal、ACS Appl. Mater. Interfaces等高水平杂志，发表SCI论文40余篇，其中一作或通讯作者30篇。授权国家发明专利15项，美国专利4项，主持国自然基金2项、国家重点研发计划子课题2项、江苏省青年基金1项、江苏省前沿引领技术基础专项子课题1项。

周跃涛，男，生理学博士，副教授；博士毕业于德国Eberhard Karls Universität Tübingen大学，2018年与2021年分别在美国UCLA David Geffen太阳集团www0638及Mayo Clinic开展学术研究。主要从事免疫系统相关的生理学功能及机制研究。已在J Biol Chem等著名国际学术期刊上发表SCI及其他论文30余篇，引用近500，受邀Frontiers in Immunology等SCI杂志任Reviewer，Guest editor角色。主持国家自然科学基金及省部级等多项科研项目。入选江苏省“双创计划”，通过无锡市太湖人才计划认定。现为德国生理学会会员，中国生理学会会员，江苏省生理学会青年委员兼教学委员。

徐非，女，生物学博士，副教授；主要从事慢性疾病的药理学研究。运用基因敲除小鼠模型及其他基因干预手段，研究自噬及自噬相关基因在免疫微环境中的调控作用。从事临床免疫调节药物扩大适应症研究。主持国家自然科学基金项目1项，国家博士后项目1项、省部级项目1项、市科技发展项目1项，企业委托项目多项。参与国家自然科学基金（面上和国际重大项目）等5项。发表SCI论文20篇，其中以第一作者身份发表SCI论文9篇。担任江苏省生理学会青年委员会委员、江苏省生理学会科普委员会委员。

朱雪雪，女，太阳集团www0638讲师。2022年获德国Eberhard Karls Universität Tübingen大学生理学博士学位。2023年1月起，在太阳集团www0638太阳集团www0638工作。研究主要集中在糖尿病、高血压、血管钙化等血管损伤机制及干预。参与国家自然科学基金1项。在SCI杂志发表论文共17篇，其中以第一或共同第一作者发表SCI论文共10篇。

蔡维维，女，硕士，助理实验师，医学硕士，2014年毕业于太阳集团www0638，主要研究方向为肿瘤药理学研究。

侯豹，男，硕士，实验师，工学硕士，2017年毕业于太阳集团www0638，主要研究方向为慢性创伤愈合及关节炎研究。

一、团队代表性科研项目

二、团队代表性科研成果

论文

1.Hou B, Wen Y, Zhu X, Qi M, Cai W, Du B, Sun H, Qiu L. Preparation and characterization of vaccarin, hypaphorine and chitosan nanoparticles and their promoting effects on chronic wounds healing. Int J Biol Macromol. 2022 Nov 30;221:1580-1592. doi: 10.1016/j.ijbiomac.2022.08.041.

2.Li T, Yu X, Zhu X, Wen Y, Zhu M, Cai W, Hou B, Xu F, Qiu L. Vaccarin alleviates endothelial inflammatory injury in diabetes by mediating miR-570-3p/HDAC1 pathway. Front Pharmacol. 2022 Sep 1;13:956247. doi: 10.3389/fphar.2022.956247.

3.Sun H, Guo Y, Wang H, Yin A, Hu J, Yuan T, Zhou S, Xu W, Wei P, Yin S, Liu P, Guo X, Tang Y, Yan Y, Luo Z, Wang M, Liang Q, Wu P, Zhang A, Zhou Z, Chen Y, Li Y, Li J, Shan J, Zhou W. Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis. Gut. 2023 Jan 5:gutjnl-2022-327756. doi: 10.1136/gutjnl-2022-327756.

4.Lu QB, Ding Y, Liu Y, Wang ZC, Wu YJ, Niu KM, Li KX, Zhang JR, Sun HJ. Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. J Adv Res. 2022 Nov 8:S2090-1232(22)00243-0. doi: 10.1016/j.jare.2022.10.014.

5.Hu J, Hu J, Wu W, Qin Y, Fu J, Zhou J, Liu C, Yin J. N-acetyl-galactosamine modified metal-organic frameworks to inhibit the growth and pulmonary metastasis of liver cancer stem cells through targeted chemotherapy and starvation therapy. Acta Biomater. 2022 Oct 1;151:588-599.

6.Hu J, Zhang J, Li L, Bao X, Deng W, Chen K. Chitosan-coated organosilica nanoparticles as a dual responsive delivery system of natural fragrance for axillary odor problem. Carbohydr Polym. 2021 Oct 1;269:118277.

7.Haijian Sun, Xuexue Zhu，Weiwei Cai,Liying Qiu*. Hypaphorine attenuates lipopolysaccharide-Induced endothelial inflammation via regulation of TLR4 and PPAR-γ dependent on PI3K/Akt/mTOR signal pathway. International Journal of Molecular Sciences.2017, 18(4). pii: E844. doi: 10.3390/ijms18040844.

8.Haijian Sun, Weiwei Cai, Xu Wang, Yanling Liu, Bao Hou, Xuexue Zhu,Liying Qiu*.Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells.BMC Complement Altern Med.2017,17(1):120. doi: 10.1186/s12906-017-1635-1.

9.Haijian Sun，Bao Hou，Xu Wang, Xuexue Zhu，Kexue Li，Liying Qiu*.Endothelial dysfunction and cardiometabolic diseases: role of long non-coding RNAs.Life Sciences，2016，167：6-11.

10.Yuyu Qiu, Bin Du, Fengshan Xie, Weiwei Cai, Yanling Liu, Yue Li, Lei Feng,Liying Qiu*.Vaccarin attenuates high glucose‑induced human EA•hy926 endothelial cell injury through inhibition of Notch signaling. Molecular Medicine Reports, 2016, 13: 2143-2150.

11.Fengshan Xie, Weiwei Cai, Yanling Liu, Yue Li, Bin Du, Lei Feng,Liying Qiu*.Vaccarin attenuates human EA.hy926 endothelial cells oxidative stress injury through Notch signaling inhibition. International Journal of Molecular Medicine. 2015, 35(1):135-142.

12.Weiwei Cai, Yue Li, Qingqing Yi, Fengshan Xie, Bin Du, Lei Feng,Liying Qiu*. Total saponins from Albizia julibrissin inhibit vascular endothelial growth factor-mediated angiogenesis in vitro and in vivo. Molecular Medicine Reports, 2015, 11(5): 3405-3413.

13.Fengshan Xie, Lei Feng, Weiwei Cai, Yuyu Qiu, Yanling Liu, Yue Li, Bin Du,Liying Qiu*. Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo. Molecular Medicine Reports.2015, 12(1): 1131-1136.

14.Yue Li, Weiwei Cai, Qingqing Yi, Fengshan Xie, Yanling Liu, Bin Du, Lei Feng,Liying Qiu*. Lipid droplets may lay a spacial foundation for vasculogenic mimicry formation in hepatocellular carcinoma. Medical Hypotheses, 2014, 83: 56–59.

15.Liying Qiu*,Liping Ma, Lei Feng, Jinzhen Han, Bin Du.The effects of vaccaria segetalis extract on inhibiting angiogenesis in vivo and its underlying mechanism. Acta Pharmacologica Sinica, 2013, 34:28.

16.Yuhai Wang,Liying Qiu, Jirong Dong, Bing Wang, Zhonghua Shi, Bin Liu, Wei Wang, Jing Zhang, Sang Cai, Gang Ye, Xuejian Cai.Comparison of the pharmacokinetics of imipenem after intravenous and intrathecal administration in rabbits. European Review for Medical and Pharmacological Sciences, 2013, 17: 711-719.

17.Jian Jin,Liying Qiu, Hui Hua, Lei Feng. The Effect of Chinese herb on tumor angiogenesis by inhibiting vessel endothelial cells. Tumor Angiogenesis, 2012, Pp67-84, InTech Rijeka, Croatia.

18.Liying Qiu*, Zhiyong Yang, Bin Du, Hongbin Fan, Yying Li, Jianqing Cheng. The change of brain metabolism and the action of aspirin after cerebral ischemia-reperfusion injury in rats. Physio Acta, 2012, 64: 206.

19.Yueying Gao,Liying Qiu*, Xiaoxing Kang, Hua Wang, Lingyan Liu, Lei Feng, Jian Jin. Anti-tumor effect and its mechanism of Vaccaria segetalis on mouse inoculated H22 solid carcinoma. Int Conf Bioinformatics Biomed Eng, iCBBE Monograph. DOI10.1109/ICBBE. 2010. 5517710.

20.Liying Qiu, Bin Du, Ying Li, Hongbin Fan, Zhiyong Yang.Anti-apoptotic effects of aspirin following cerebral ischemia-reperfusion injury in rats. Neural Regen Res, 2008, 3(9)：979-984.

21.Liying Qiu, Ying Li, Zhiyong Yang, Bin Du, Hongbin Fan.Changes in neuronal apoptosis and apoptosis modulatory factors in cerebral ischemia/reperfusion. Neural Regen Res, 2007, 2(6): 344-349.

22.Jing Hu, Peter H. Seebergerb, Jian Yin. Using carbohydrate-based biomaterials as scaffolds to control human stem cell fate. Organic and Biomolecular chemistry, 2016, 14, 8648-8658.

23.Jing Hu, Liying Qiu, Xiaoli Wang, Xiaopeng Zou, Mengji Lu (Professor), Jian Yin. Carbohydrate-based vaccine adjuvants – discovery and development. Expert Opinion On Drug Discovery, 2015, 10(10), 1133-1144.

24.Jing Hu, Jia Liu, Dongliang Yang, Mengji Lu and Jian Yin. Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs. Protein & Peptide Letters, 2014, 21(10), 1025-1030.

25.Jing Hu, Werner Reutter and Hua Fan, Significance of N-glycosylation and sialylation of GABA transporter 1. Journal of Carbohydrate Chemistry, 2011, 30(4-6): 206-17.

26.Jing Hu,Jian Fei,Werner Reutter, Hua Fan.Involvement of Sialic Acid in the Regulation of GABA Uptake Activity of GABA Transporter 1, Glycobiology, 2011, 21(3): 329-339.

27.Hua Fan, Felista Lemnyui Tansi, Wilhelm Andreas Weihofen, Christoph Böttcher,Jing Hu, Jacobo Martinez, Wolfram Saenger, Werner Reutter.Molecular mechanism and structural basis of interactions of dipeptidyl peptidase IV with adenosine deaminase or human immunodeficiency virus type-1 transcreiption transactivator, European Journal of Cell Biology, 2012,91(4):265-273.

28.Guangzong Tian, Xiaoli Wang,Jing Hu, Xuebin Wang, Xiaoqiang Guo, Jian Yin. Recent Progress of Sugar Amino Acids: Synthetic Strategies and Applications as Glycomimetics and Peptidomimetics, Chinese Chemical Letters, 2015, 26(08), 922-930.

29.Xiaoli Wang, Xueyu Wang, Beilei Zhang, Dawei Song,Jing Hu, Jian Yin.Current status and applications of aminoglycoside microarrays. Pakistan Journal of Pharmaceutical Sciences, 2016.

30.Zhonghua Lu, Wei Chen, Chaoxia Ju, Jun Den, Shougang Kuai, Hao Pei, Lihua Huang, Xibing Gu, Yongxiang，Ying, Xiqi Hu, Tengfang Zhu, Yiping Xing and Qinhe Fan.CD25 Is a Novel Marker of Hepatic Bile Canaliculus.International Journal of Surgical Pathology, 2012,20(5):455-461.

31.Zhonghua Lu, Xiaoping Huang, Wei Sun, Yiling Zhu, Juanjuan Cui, Wei Chen, Lihua Huang, Shougang Kuai, Hejuan Du, Zhaoxia Ju, Jianhe Gan. T helper cell dysregulation with hepatitis B and rebalance with glucocorticoids. World J Gastroenterol, 2014,20(48): 18354-18359.

32.Zhonghua Lu, Wei Chen, Zhaoxia Ju, Hao Pei, Xiaojuan Yang, Xibing Gu and Lihua Huang. Pathological Features and Prognosis in Chronic Hepatitis B Virus Carriers. The Journal of International Medical Research, 2011,39(1):71-77.

33.Xibing Gu, Xiaojuan Yang,Zhonghua Lu, Zhao Bo, Yinfang Zhu, Hangyuan Wu, Yiming Jiang, Haokun Chen, Hao Pei. Effect of oxymatrine on specific cytotoxic T lymphocyte surface programmed death receptor-1 expression in patients with chronic hepatitis B. Chin Med J (Engl), 2012,125(8):1434-1438.

34.Zhitao Yang, Suyuan Huang, Li Chen, Feng Liu, Xiaohui Cai, Yangfan Guo, Mingjie Wang, Yue Han, Demin Yu, Jiehong Jiang, Donghua Zhang, Qiming Gong, Guoqing Zhang, Guoqing Zang,Zhonghua Lu, Lihua Huang, Xinxin Zhang. Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection. Journal of Clinical Microbiology, 2015,53(6):2203-2214.

35.Yan Yan, Kai Hu, Xu Deng, Xinmeng Guan, SukunLuo, Lina Tong, Tao Du, Ming Fu, Mudan Zhang, Yalan Liu, Qinxue Hu. Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge. The Journal of Immunology. 2015, 195(1): 329-338.

36.Ni Zeng*，Yuetao Zhou*，Shaqiu Zhang，Yogesh Singh，Madhuri S. Salker，Bing Shi，Florian Lang.1α,25(OH) 2D3Sensitive Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Ishikawa Cells. Cell Physiol Biochem. 2017，41(2):678-688.

37.Yogesh Singh*,Yuetao Zhou*, Xiaolong Shi, Shaqiu Zhang, Anja T Umbach, Madhuri S Salker, Karl S Lang, Florian Lang. Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells. J Biol Chem. 2016，291(45):23662-23671.

38.Yuetao Zhou, Xiaolong Shi, Hong Chen, Shaqiu Zhang, Madhuri S Salker, Andreas F Mack, Michael Föller, Tak W. Mak, Yogesh Singh, Florian Lang. DJ-1/Park-7 sensitive pH and sodium hydrogen exchanger 1 (NHE1) activity in CD4+ T cells. J Cell Physiol 2016 Aug 10. doi: 10.1002/jcp.25516.

39.Yuetao Zhou, Madhuri S. Salker, Britta Walker, Patrick Münzer, Oliver Borst, Meinrad Gawaz, Erich Gulbins, Yogesh Singh, Florian Lang. Acid Sphingomyelinase (ASM) is a negative regulator of regulatory T cells (Tregs) development Cell Physiol Biochem 2016，39(3):985-995.

40.Yuetao Zhou, Venkanna Pasham, Soumya Chatterjee, Anand Rotte, Wenting Yang, Madhuri Bhandaru, Yogesh Singh, Florian Lang. Regulation of Na+/H+ Exchanger in Dendritic Cells by Akt1. Cell Physiol Biochem 2015，36:1237-1249

41.Madhuri S. Salker*,Yuetao Zhou*, Yogesh Singh, Jan Brosens, Florian Lang. LeftyA sensitive cytosolic pH regulation and glycolytic flux in Ishikawa human endometrial cancer cells. Biochem Biophys Res Commun. 2015，460(3):845-9.

42.Yixiang Li,Yuetao Zhou, Xiaobing Wang, Pan Wang, Yaping Xiao, Xiaoxia Cheng, Yanhua Zhang, Yilin Liu, Quanhong Liu. Fruit Extract from Pyropolyporus fomentarius (L. ex Fr.) Teng Induces Mitochondria-Dependent Apoptosis in Leukemia Cells but Enhances Immunomodulatory Activities of Splenic Lymphocytes. Nutr Cancer. 2016 Apr 26:1-10.

43.Yogesh Singh, Hong Chen,Yuetao Zhou, Michael Föller, Tak W. Mak, Madhuri S. Salker, Florian Lang. Differential effect of DJ-1/Park-7 on development of natural and induced regulatory T cells. Sci Rep.2015 Dec 4;5:17723.

44.Shaqiu Zhang, Tamer al-Maghout,Yuetao Zhou, Rosi Bissinger, Abeer Abousaab, Madhuri S. Salker, Lisann Pelzl, Bradley S. Cobb, Anchun Cheng, Yogesh Singh Florian Lang. Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4+ T cells. Cell Physiol Biochem 2016;39.

45.Rosi Bissinger, Abaid Malik, Ghada Bouguerra,Yuetao Zhou, Yogesh Singh, Salem Abbès, Florian Lang. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2015 Oct 12.

46.Xiaoxia Cheng, Yaping Xiao, Pan Wang, Xiaobing Wang,Yuetao Zhou, Han Yan, Quanhong Liu. The ethyl acetate fraction of Polytrichum commune L.ex Hedw induced cell apoptosis via reactive oxygen species in L1210 cells,J Ethnopharmacol, 2013 Jul 30;148(3):926-33.

47.Hongxia Li, Pan Wang, Quanhong Liu, Xiaoxia Cheng,Yuetao Zhou, Yaping Xiao. Cell cycle arrest and cell apoptosis induced by Equisetum hyemale extract in murine leukemia L1210 cells, J Ethnopharmacology, 2012 Nov 21;144(2):322-7.

48.Haijian Sun, Mingxia Zhao, Xingsheng Ren, Tongyan Liu, Qi Chen, Yuehua Li, Yuming Kang, Juejin Wang, Guoqing Zhu. Salusin-β Promotes Vascular Smooth Muscle Cell migration and Intimal Hyperplasia after Vascular Injury via ROS/NFκB/MMP-9 Pathway. Antioxidants & Redox Signaling, 2016,24(18):1045-1057.

49.Haijian Sun, Mingxia Zhao, Tongyan Liu, Qi Chen, Yuehua Li, Yuming Kang, Juejin Wang, Guoqing Zhu.Salusin-β induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFκB pathway. Scientific Reports, 2016,23;6:23596.

50.Haijian Sun, DanChen,Ying Han,YeboZhou, Juejin Wang, Qi Chen, Yuehua Li, XingyaGao, Yuming Kang, Guoqing Zhu. Relaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway.Neuropharmacology,2016,103:247-256.

51.Haijian Sun, Tongyan Liu, Feng Zhang, Xiaoqing Xiong, Juejin Wang, Qi Chen, Yuehua Li, Yuming Kang,YeboZhou,Ying Han, XingyaGao, Guoqing Zhu.Salusin-β contributes to vascular remodeling associated with hypertension via promoting vascular smooth muscle cell proliferation and vascular fibrosis.Biochimica et biophysica acta-molecular basis of disease, 2015,1852(9):1709-1718.

52.Haijian Sun, Lingli Zhang, Zhidan Fan, Dan Chen, Lei Zhang, XingyaGao, Yuming Kang, Guoqing Zhu.Superoxide anions involved in sympathoexcitation and pressor effects of salusin-β in paraventricular nucleus in hypertensive rats.Acta Physiol (Oxf) ,2014,210(3):534-545.

53.Haijian Sun, Hong Zhou, Feng Xuemei, qing Gao, Ding Lei, Chaoshu Tang, Guoqing Zhu,YeboZhou.Superoxide anions in the paraventricular nucleus mediate cardiac sympathetic afferent reflex in insulin resistance rats.Acta Physiol (Oxf), 2014,212(4):267-282.

54.Haijian Sun, Peng Li, Weiwei Chen, Xiaoqing Xiong, Ying Han.Angiotensin II and angiotensin-(1-7) in paraventricular nucleus modulate cardiac sympathetic afferent reflex in renovascular hypertensive rats.PLoS One, 2012,7(12):e52557.

55.Peng Li,Haijian Sun, Baiping Cui,YeboZhou, Ying Han.Angiotensin-(1-7) in the rostral ventrolateral medulla modulates enhanced cardiac sympathetic afferent reflex and sympathetic activation in renovascular hypertensive rats.Hypertension, 2013,61(4):820-827.

56.YeboZhou,Haijian Sun, Dan Chen, Tongyan Liu, Ying Han, Juejin Wang, Chaoshu Tang, Yuming Kang, Guoqing Zhu.Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats.Hypertension, 2014,63(2):330-337.

57.Fei Xu, Ruitang Cheng, Sunhan Miao, Yuwei Zhu, Ze Sun, Liying Qiu, Junqi Yang, Yonghua Zhou. Prior Toxoplasma Gondii Infection Ameliorates Liver Fibrosis Induced by Schistosoma Japonicum Through Inhibiting Th2 Response and Improving Balance of Intestinal Flora in Mice. Int J Mol Sci. 2020 Apr 14;21(8):2711.

58.Taiyue Li, Xiaoyi Yu, Xuerui Zhu, Yuanyuan Wen, Meizhen Zhu, Weiwei Cai, Bao Hou,Fei Xu, Liying Qiu. Vaccarin alleviates endothelial inflammatory injury in diabetes by mediating miR-570-3p/HDAC1 pathway. Front. Pharmacol. 2022;13:956247.

59.Fei Xu, Yixiao Liu, Xuexue Zhu, Shuangshuang Li, Xuelin Shi, Zhongjie Li, Min Ai, Jiangnan Sun, Bao Hou, Weiwei Cai, Haijian Sun, Lulu Ni, Yuetao Zhou and Liying Qiu. Protective Effects and Mechanisms of Vaccarin on Vascular Endothelial Dysfunction in Diabetic Angiopathy. Int. J. Mol. Sci. 2019, 20, 4587.

60.Yixiao Liu 1, Jiangnan Sun 1, Xinyu Ma, Shuangshuang Li, Min Ai,Fei Xu *and Liying Qiu *. Vaccarin Regulates Diabetic Chronic Wound Healing through FOXP2/AGGF1 Pathways. Int. J. Mol. Sci. 2020, 21, 1966.

61.Xuexue Zhu, KeMa, Kuo Zhou, Xia Pan, Jibin Liu, Bernd Nürnberg, Ioana Alesutan, Jakob Völkl, Florian Lang. Requirement of Na⁺/H⁺exchanger NHE1 for vasopressin-induced osteogenic signaling and calcification in human aortic smooth muscle cells.Kidney Blood Press Res.2022, 47(6):399-409.

62.Xuexue Zhu, KeMa, Kuo Zhou, Jibin Liu, Bernd Nürnberg, Florian Lang.Vasopressin-stimulated ORAI1 Expression and Store-operated Ca²⁺Entry in Aortic Smooth Muscle Cells.J Mol Med (Berl). 2021, 99(3):373-382.

63.Xuexue Zhu, KeMa, Kuo Zhou, Jakob Völkl, Ioana Alesutan, Leibrock C, Nürnberg B, Lang F. Reversal of phosphate-induced ORAI1 expression, store-operated Ca²⁺entry and osteogenic signaling by MgCl₂in human aortic smooth muscle cells.Biochem Biophys Res Commun. 2020, 523(1):18-24.

64.Xuexue Zhu,Zhou Zhou, Qingfeng Zhang, Weiwei Cai, Yuetao Zhou, Haijian Sun, Liying Qiu. Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats.J Cell Biochem. 2018, 119(1):926-937.

65.Xuexue Zhu,Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qiu. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress.Eur J Pharmacol. 2018, 818:371-380.

专利

1.邱丽颖，谢凤珊，冯磊，杜斌，蔡维维，李曰，金坚。一种具有抗氧化抗高糖损伤的王不留行黄酮苷的应用，授权号：ZL 201410195552.2

2.邱丽颖，冯磊，洪奎，马丽萍，谢凤珊，孙娟，苏晓琴。一种同时分离王不留行黄酮苷和王不留行总皂苷的分离方法，授权号：ZL 2012 1 0512777.7

3.邱丽颖，冯磊，马丽萍，洪奎。一种具有促进血管生成的王不留行黄酮苷的应用，授权号：ZL 2012 1 0512699.0

4.胡勤学，阎岩，胡凯，一种双价DNA疫苗链接肽及其应用，ZL201410132066.6

5.Kuhn M, Campillos M, Jensen LJ, Bork P, Gavin AC, Luciani R, Fan H, Hossbach J,Hu J, Ahmed J and Preissner R. Aprepitant as antineoplastic drug，US patent application 61/043299.

6.邱丽颖，冯磊，陈旭红，刘艳玲，冯柏年，杜斌，金坚。一种王不留行刺桐碱单体的制备方法，公开号：CN104030965A。

7.邱丽颖，谢凤珊，冯磊，杜斌，蔡维维，李曰，金坚。一种具有抗氧化抗高糖损伤的王不留行黄酮苷的应用，公开号：CN103948619A。

8.邱丽颖，刘艳玲，杜斌，冯磊，王旭，蔡维维，谢凤珊，李曰，侯豹，赵霞，赵庆，顾蓉。王不留行黄酮苷用于治疗开放性皮肤损伤的应用，公开号：CN105168234A。

9.邱丽颖，侯豹，陈宇潇，冯磊，刘艳玲，王旭，蔡维维，杜斌，金坚。一种王不留行黄酮苷软膏剂的制备方法，公开号：CN105106106A。

10.邱丽颖，冯磊，王旭，蔡维维，刘艳玲，侯豹。SonoVue超声造影技术在诊治肿瘤血管生成拟态中的检查指标，公开号：CN105879064A。

获奖

1.邱丽颖，冯磊，杜斌，花慧，金坚。具有抗肿瘤新生血管活性的中药研究及其开发应用，无锡市科技进步奖三等奖，无锡市人民政府，2013年。

2.邱丽颖，花慧，冯磊，杜斌，金坚。合欢皮抗肿瘤新生血管活性研究及其临床组方应用。中国商业联合会科技进步三等奖，中国商业联合会，2011年。

3.邱丽颖，吕莉，焦宏，马建伟，王德宝，温晓竞，王雪芳，边永玲。高血压大鼠血管平滑肌钙调神经磷酸酶活性变化及心肌电学酶学特征。张家口市科技进步二等奖，张家口市科学技术局，2005年。

4.陆忠华，黄利华，邢益平，肝组织炎症活动度在慢性乙型肝炎病毒携带者病情激活中的应用，江苏省医学新技术引进奖二等奖，江苏省卫生和计划生育委员会，2014年。

5.陆忠华，邢益平，黄利华，CD25在人肝毛细胆管表达的研究及意义，江苏省医学新技术引进奖二等奖，江苏省卫生厅，2008年。

6.吴鹏西，徐卓群，周锋盛，邵剑锋，邱丽颖。SonoVue超声造影在实体肿瘤的基础及临床研究，无锡市科技进步奖三等奖，无锡市人民政府，2012年。

7.付学功，邱丽颖，牛伶锐，白普一，王志平，刘世同，张冠华。医用麦芽生产技术研究及推广应用。安阳市科技进步三等奖，安阳市人民政府，2010年。

8.陈彦静，张晓云，葛赋贵，邱丽颖，李建东，王德宝，马建伟，焦宏。心室流出道电生理特征及其心律失常关系的研究。张家口市科技进步一等奖，张家口市科学技术局，2005年。

9.张静，牛春雨，樊贵，刘艳凯，张学锋，葛琳，张杰，李荣，赵自刚，邱丽颖。肠淋巴液对血压的影响及其抗休克作用。张家口市科技进步一等奖，张家口市科学技术委员会，2001年。

六、团队合影